Vigabatrin Monotherapy for Infantile Spasms
نویسندگان
چکیده
منابع مشابه
Clinical profile of vigabatrin as monotherapy for treatment of infantile spasms
Vigabatrin, the first therapeutic agent to be approved by the Food and Drug Administration for the treatment of infantile spasms, as well as for adjunctive use in the treatment of refractory complex partial epilepsy, represents an important advance for patients with difficult-to-manage epilepsy. This review summarizes the complex history, chemistry, and pharmacology, as well as the clinical dat...
متن کاملThe use of vigabatrin in infantile spasms in Asian children.
BACKGROUND The use of adrenocorticotrophic hormone (ACTH) and prednisolone in the management of infantile spasms has been well established, but is associated with significant morbidity and cannot be used as long-term medication. Since the introduction of vigabatrin, results have been promising with suggestions currently that it should be used as first-line management of infantile spasms. AIM ...
متن کاملVigabatrin versus ACTH in the treatment of infantile spasms.
OBJECTIVE To compare adrenocorticotropic hormone with vigabatrin as a single mono-therapy for infantile spasms. We studied hospitalization time, clinical response, whether complete or partial, time taken for improvement, and presence or absence of recurrence after stopping the medication. Together with improvement of electroencephalographic changes, and time taken for significant response, neur...
متن کاملVigabatrin retinal toxicity in children with infantile spasms
OBJECTIVES To determine time to vigabatrin (VGB, Sabril; Lundbeck, Deerfield, IL) induced retinal damage in children with infantile spasms (IS) and to identify risk factors for VGB-induced retinal damage (VGB-RD). METHODS Observational cohort study including 146 participants (68 female, 81 male) with IS, an age-specific epilepsy syndrome of early infancy, treated with VGB. Participants ranged...
متن کاملtreatment of infantile spasms; tetracosectide or vigabatrin? a comparative study
objective: infantile spasms (is) is an age specific epileptic syndrome. due to poor response of is to conventional antiepileptic drugs, scientists are always on the lookout for newer, more effective drugs to treat the condition. materials & methods: in this study, 50 infants with is symptoms, aged between 2-24 months, were randomly divided into two equal groups, each treated either with vigabat...
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ژورنال
عنوان ژورنال: Pediatric Neurology Briefs
سال: 1995
ISSN: 2166-6482,1043-3155
DOI: 10.15844/pedneurbriefs-9-3-2